Abstract: Objective: To evaluate the clinical efficacy of radical esophagectomy combined with chemoradiotherapy in patients with
advanced esophageal cancer and its impact on immune function. Methods: Ninety-eight patients with advanced esophageal cancer ad⁃
mitted to Shuyang County Traditional Chinese Medicine Hospital between December 2023 and January 2025 were randomly divided
into a control group (radical surgery alone) and an intervention group (radical surgery plus chemoradiotherapy). Clinical efficacy, im⁃
mune function indicators, serum tumor markers, and adverse reactions were compared between groups. Results: The total effective rate
in the intervention group was significantly higher than that in the control group (P<0.05). After 12 weeks of treatment, the intervention
group showed significantly increased in CD3+ levels and decreased in CD4+ and CD8+ levels，and the ratio of CD4+/CD8+, along with re⁃
duced serum levels of carcinoembryonic antigen and cyto-keratin-19 fragment antigen 21-1 (P<0.01). No significant difference in ad⁃
verse reaction rates was observed between groups (P>0.05). Conclusion: Radical esophagectomy combined with chemoradiotherapy
significantly improves treatment efficacy, enhances immune function, and reduces tumor marker levels in patients with advanced
esophageal cancer, demonstrating favorable safety and clinical application value.

Key words: esophageal cancer, radical surgery, chemoradiotherapy, immune function, serum tumor markers